Use advanced drying equipment to serve the pharmaceutical industry
With the rapid development of society, people are more demanding and more selective about drugs. Although Western European countries have advanced technology and equipment, due to their high costs for environmental protection and labor, these countries have difficulties in maintaining the production of APIs and intermediates. Therefore, there is a tendency for foreign pharmaceutical companies to turn to developing countries to invest and set up factories. Undoubtedly, China is an ideal country to invest in, with sufficient manpower and material resources. In recent years, China's pharmaceutical industry has made considerable progress.
At present, domestic pharmaceutical companies have no shortage of advanced technologies and advanced technologies. However, in order to produce higher-quality pharmaceuticals, pharmaceutical equipment is also of great importance.
Our company was established in 1976 and has been engaged in the research, development and manufacturing of pharmaceutical drying equipment. In 1981, it cooperated with the Shanghai Institute of Pharmaceutical Industry to develop a low-energy aseptic spray dryer unit and a double-cone rotary dryer unit. So far there have been more than 20 years of production history.
GMP's drug regulations expressly state that all pharmaceutical equipment must comply with GMP production requirements and must be capable of in-situ cleaning and in-situ sterilization. During the operation of the equipment, there must be no secondary pollution to the medicine. To address this requirement, we use a positive pressure drying process for low-energy aseptic spray drying equipment. 0.5u of dust particles in the hot air entering the tower does not exceed 10/liter. Operating temperature can be 0--150 °C, using a three-fluid nozzle. The vapor-liquid contact is good, atomization is even, and it conforms to aseptic operation. Due to the good contact of the mist and the short drying time, the dry strength can reach about 7 kg (water)/m3•hour.
For the crystalline material, it is dewatered by a centrifuge filter and placed in a drying oven. In order to make the material more capable of achieving asepsis production requirements in the drying process, the double-cone rotary drying unit produced by the company has the following features: 1) The dryer is cylindrical in the middle, and the top of the cone is provided with inlet and outlet ports and a hole. The device consists of three layers: the jacket is heated in the middle and the outer layer is insulated with glass fiber. The energy consumption is very low. The material is put in the inner layer and it is rotated and dried under vacuum conditions to prevent the material from coming back into contact with the body for a long time. phenomenon. The drying time is only about 2/3 of the drying time required for similar materials in a vacuum oven, which improves labor efficiency. 2) In the drying process, it is not only required that the wall of the tube be heated evenly, but also the sealing of the vacuum is required to be better. The bicone produced by our company is equipped with a deflector device inside the jacket, which not only increases the strength of the cylinder, but also stipulates that the hot water does not go short circuit. The vacuum pumping end surface not only requires large, but also requires good sealing. We use rare metal cobalt and nylon contacts to increase wear resistance and maintain better sealing under vacuum conditions. 3) The entire equipment must have a good stability and good concentricity during operation so that the seals on both sides can maintain a good condition. The two bearing racks of our company's equipment are all welded with carbon steel plates and machined two mounting surfaces on a planer. After the shafts are welded to the barrels, two shaft holes are machined on the coordinate boring machine. The shaft is welded into the shaft sleeve to ensure that the concentricity of the two shafts is within 0.14mm (below 1000L) and the guarantee of the 5000L is within 0.22mm, so that the entire equipment is high in strength, stable in operation, and not easily deformed.
In order to better reduce costs, increase production efficiency, and reduce labor intensity in the pharmaceutical process, our company developed filtration, washing, and drying “triple play†devices in 2000 based on foreign materials. The device can complete filtration, washing (bleeding) and drying in a sealed container. The device can replace the filtration and drying equipment at the same time, and can realize continuous operation in the whole closed and whole process, and is more suitable for the production of aseptic products and toxic products.
In the filtration stage, the crystal body and the mother liquor are separated and operated under a pressurized vacuum condition. The smoothing of the filter cake is achieved by the scraping of the S-type stirring blade, and compaction is performed, so that the solid-liquid separation effect is better. A special rotating spray device is arranged in the container so that the cleaning liquid is evenly distributed in the container. The inside of the container can be cleaned and the material can be cleaned. Through the rotation and lifting of the stirring blade, the filter cake and the cleaning liquid can be mixed more uniformly. The slurry cake was thoroughly washed. The filtered filter cake is scraped and heated by the stirring slurry layer by layer to heat the entire barrel body, the chassis, and the blade to scrape the material, and the side discharge device is opened. The pulp is automatically discharged from the discharge port on the side of the tank wall through the pushing of the blade.
In order to reduce the investment of equipment and fewer equipment procedures in the processing of pharmaceuticals, our company has developed a “five-in-one†device based on the double cone, which means that crystallization, reaction, filtration, and washing are realized in one device. Drying five processes. At the end of the double cone is designed as a circular arc bottom, and a stirrer blade is designed; in the reaction and crystallization, the cone is face down, and uniform crystallization and reaction are achieved through stirring of the stirring blade; after crystallization and reaction, the cone is made Rotate 180°C. At one end of the cone, a filter sintered mesh device is designed. After the suction filter is connected, the mother liquor is suction filtered, and the washing liquid is passed through the washing interface. The filter cake is washed during the slewing process. After the washing is completed, as in the drying process of the double cone, in order to prevent the material from pilling, it is also possible to start stirring the crushed material. After drying, open the end cap discharge (same double cone) and clean the material at one time. Therefore, this kind of equipment is more practical and combines the advantages of the tank type three-in-one and double-cone.
At present, domestic pharmaceutical companies have no shortage of advanced technologies and advanced technologies. However, in order to produce higher-quality pharmaceuticals, pharmaceutical equipment is also of great importance.
Our company was established in 1976 and has been engaged in the research, development and manufacturing of pharmaceutical drying equipment. In 1981, it cooperated with the Shanghai Institute of Pharmaceutical Industry to develop a low-energy aseptic spray dryer unit and a double-cone rotary dryer unit. So far there have been more than 20 years of production history.
GMP's drug regulations expressly state that all pharmaceutical equipment must comply with GMP production requirements and must be capable of in-situ cleaning and in-situ sterilization. During the operation of the equipment, there must be no secondary pollution to the medicine. To address this requirement, we use a positive pressure drying process for low-energy aseptic spray drying equipment. 0.5u of dust particles in the hot air entering the tower does not exceed 10/liter. Operating temperature can be 0--150 °C, using a three-fluid nozzle. The vapor-liquid contact is good, atomization is even, and it conforms to aseptic operation. Due to the good contact of the mist and the short drying time, the dry strength can reach about 7 kg (water)/m3•hour.
For the crystalline material, it is dewatered by a centrifuge filter and placed in a drying oven. In order to make the material more capable of achieving asepsis production requirements in the drying process, the double-cone rotary drying unit produced by the company has the following features: 1) The dryer is cylindrical in the middle, and the top of the cone is provided with inlet and outlet ports and a hole. The device consists of three layers: the jacket is heated in the middle and the outer layer is insulated with glass fiber. The energy consumption is very low. The material is put in the inner layer and it is rotated and dried under vacuum conditions to prevent the material from coming back into contact with the body for a long time. phenomenon. The drying time is only about 2/3 of the drying time required for similar materials in a vacuum oven, which improves labor efficiency. 2) In the drying process, it is not only required that the wall of the tube be heated evenly, but also the sealing of the vacuum is required to be better. The bicone produced by our company is equipped with a deflector device inside the jacket, which not only increases the strength of the cylinder, but also stipulates that the hot water does not go short circuit. The vacuum pumping end surface not only requires large, but also requires good sealing. We use rare metal cobalt and nylon contacts to increase wear resistance and maintain better sealing under vacuum conditions. 3) The entire equipment must have a good stability and good concentricity during operation so that the seals on both sides can maintain a good condition. The two bearing racks of our company's equipment are all welded with carbon steel plates and machined two mounting surfaces on a planer. After the shafts are welded to the barrels, two shaft holes are machined on the coordinate boring machine. The shaft is welded into the shaft sleeve to ensure that the concentricity of the two shafts is within 0.14mm (below 1000L) and the guarantee of the 5000L is within 0.22mm, so that the entire equipment is high in strength, stable in operation, and not easily deformed.
In order to better reduce costs, increase production efficiency, and reduce labor intensity in the pharmaceutical process, our company developed filtration, washing, and drying “triple play†devices in 2000 based on foreign materials. The device can complete filtration, washing (bleeding) and drying in a sealed container. The device can replace the filtration and drying equipment at the same time, and can realize continuous operation in the whole closed and whole process, and is more suitable for the production of aseptic products and toxic products.
In the filtration stage, the crystal body and the mother liquor are separated and operated under a pressurized vacuum condition. The smoothing of the filter cake is achieved by the scraping of the S-type stirring blade, and compaction is performed, so that the solid-liquid separation effect is better. A special rotating spray device is arranged in the container so that the cleaning liquid is evenly distributed in the container. The inside of the container can be cleaned and the material can be cleaned. Through the rotation and lifting of the stirring blade, the filter cake and the cleaning liquid can be mixed more uniformly. The slurry cake was thoroughly washed. The filtered filter cake is scraped and heated by the stirring slurry layer by layer to heat the entire barrel body, the chassis, and the blade to scrape the material, and the side discharge device is opened. The pulp is automatically discharged from the discharge port on the side of the tank wall through the pushing of the blade.
In order to reduce the investment of equipment and fewer equipment procedures in the processing of pharmaceuticals, our company has developed a “five-in-one†device based on the double cone, which means that crystallization, reaction, filtration, and washing are realized in one device. Drying five processes. At the end of the double cone is designed as a circular arc bottom, and a stirrer blade is designed; in the reaction and crystallization, the cone is face down, and uniform crystallization and reaction are achieved through stirring of the stirring blade; after crystallization and reaction, the cone is made Rotate 180°C. At one end of the cone, a filter sintered mesh device is designed. After the suction filter is connected, the mother liquor is suction filtered, and the washing liquid is passed through the washing interface. The filter cake is washed during the slewing process. After the washing is completed, as in the drying process of the double cone, in order to prevent the material from pilling, it is also possible to start stirring the crushed material. After drying, open the end cap discharge (same double cone) and clean the material at one time. Therefore, this kind of equipment is more practical and combines the advantages of the tank type three-in-one and double-cone.
Industrial Sliding High Speed Door Stainless Steel Door
SHENZHEN HONGFA AUTOMATIC DOOR CO., LTD , https://www.hongfarrs.com