Development of Optical Purity Measurements with New Chiral Sensitive Technologies
A research team successfully developed from the National Institute for Materials Science, young scientists at the International Agency for the Independence Administrative Agency Dr. Ishihara Shigeki, a MANA ICYS researcher Charles University Prague and other researchers, working together on simple measurements and chiral optical purity New technology. This technology provides excellent simplicity and practicality, and its high versatility has also been confirmed.
Some molecules are mirror-symmetric and have a property or "chirality," which means that different chiral molecules are mirror images of each other. That is, although they have the same shape, these shapes are like a person's right and left hands and cannot be superimposed on each other. (Actually, chiral molecules are often referred to as "right hand" or "left handed") properties and the activity of chiral organic molecules and biological macromolecules, even if the molecules are completely different, have the same chemical formula. For example, when a left-handed mutated molecule called bupivacaine is a potent analgesic, a right-handed variant shows the heart. This example shows that sensing technology, which can distinguish chirality between right and left hands, and determining the chirality of its optical purity are extremely important.
Optical purity is a key parameter of chiral molecules and represents the ratio of right-handed and left-handed molecules. In particular, in the manufacture of goods, in addition to the quality control of medical products, it is also important to synthesize and optimize the manufacturing process at each stage to determine its optical purity. For this reason, it is required to develop a simple, inexpensive technology.
In this study, the Mana-dominated team successfully developed a new technique that decided to use nuclear magnetic resonance (NMR) and a new structural symmetry porphyrin resolving agent that was independently developed by the team for optical purity. The key feature in this study was the use of a symmetrical porphyrin solution without chiral structure. This means that the molecules do not form structural isomers (diastereomers), even when they bind to a chiral measuring object (eg, a molecule). This unique feature clearly distinguishes similar conventional studies from the current study.
The mechanism of this technique is based on the subdivision of structural symmetry of the porphyrin resolving agent for chiral molecule binding, which is the identification of binding equilibrium equations, quantum mechanical calculations and molecular dynamics simulations. Development of Resolving Agents Symmetrical achiral porphyrins provide high versatility and universality, allowing measurement of optical purity of chiral molecules such as chirality, esters, protected amino acids, ketones, alcohols, and other Different kinds of animals.
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