Vacuum Freeze Dryer Selection Guide
Vacuum freeze dryer selection tips:
For each freeze-dried application field, Biomedical Solutions proposes different solutions.
For scientific research institutes and universities, Biomedical launched the FD and Lab series vacuum freeze dryers. FD series vacuum freeze-drying machine is suitable for experimental freeze-drying applications where the amount of sample is small and the freeze-drying process is relatively simple. In addition to the FD series directly drying directly in the cold trap, under normal circumstances the drying process is from room temperature to the product maximum allowable temperature, FD series can meet the demand to determine from the following points:
1. The product eutectic point and eutectic point temperature are not lower than -20°C.
2. In the case where the amount of sample loaded is less than 5 μl, no surface dissolution will occur during the establishment of the vacuum from the end of the pre-freeze.
3. The ultimate vacuum required for freeze-drying process is not less than 8Pa.
4. Freeze-drying process is relatively simple and does not require process control of pre-freezing temperature and vacuum.
FD Series Vacuum Freeze Dryer Difference Description:
1.FD3/4/5/8 is suitable for small test and pilot production with relatively low process requirements.
2.The FD-2 series is suitable for freeze-drying products containing a small amount of organic solvents, and can be pre-frozen at low temperature (in cold trap) for a small amount of sample (<1.5L). The main aspect of the FD-2 series over the FD-1 series is the configuration of a partition temperature control system and a PLC+ touch screen control system. The main difference between the FD-2 series and the Lab-1 series is that the FD-2 series is the basic model and cannot be configured for all the advanced functions Lab has (vacuum control system, pulse backfill system, defrost system, automatic drainage system, and APS. Automatic Control System).
3.FD-1 series is suitable for lyophilization applications with lower process requirements. This series provides the basic functions of lyophilization: pre-freezing in the cold trap, vacuuming, and trap trapping. The Lab-1 series can be selected for more advanced application functions.
Lab-1 Series Applications:
1. The degree of vacuum needs to be adjusted during lyophilization.
2. Sublimation and analytical drying require temperature control.
3. A higher ultimate vacuum is required during lyophilization.
4. Automatic defrosting, automatic drainage function.
5. Freeze-drying data and curve search function.
6. Pulsation backfill after lyophilization.
7. The product eutectic point and eutectic point temperature are not lower than -20°C.
8. Deliquescence occurs during the establishment of a vacuum in the trace sample.
9. Lab-1 series process optimization rate can reach 30%.
The Pilot1-2LD/Pilot1-2MD/Pilot2-4LD/Pilot2-4MD models are suitable for laboratory pilot tests. This series proposes solutions for the following problems.
1. After the product is pre-frozen, deliquescence occurs during transfer.
2. Trace samples deliquescence during the establishment of a vacuum.
3. The pre-freezing temperature needs to be adjusted during the pre-freezing of the sample.
4. Sample analysis requires a lower vacuum during drying.
5. Meet the laboratory requirements of full-featured and relatively small-footprint vacuum freeze dryer requirements.
6. The process optimization rate is 40-70%.
The Pilot series is suitable for small-scale and pilot-scale production and is suitable for the exploration and optimization of production processes for industrial materials, foods and health products (up to 65% process optimization rate).
The Pilot series of standard models are suitable for small-scale testing and pilot-scale R&D of pharmaceuticals and biological agents. Users can choose to use wall insulation and non-wall insulation according to the cleanliness requirements. The series of process optimization rate of the series can reach more than 90%, fully meet the GMP and FDA requirements.
The LYO series is mainly used for freeze-drying production. The basic type, CIP type and SIP type can be selected according to user requirements. Applications include freeze-drying of chemicals, biological drugs, biological agents, Chinese medicines, health products, high-grade foods, spices, feed additives, and industrial special applications.
Domestic and foreign vacuum freeze dryer selection guide vacuum freeze dryer market brand, many customers do not have the ability to select brands. From the perspective of market supply, it is mainly divided into: imported brands and domestic brands. The relative price of imported brands is relatively high and the performance is higher than that of domestic brands. Compared with imported brands, domestic brands have relatively low prices and relatively simple functions. The main basis for selecting an imported brand or a domestic brand is:
1. The process requirements of freeze-drying process are relatively high, and the domestic vacuum freeze-drying machine cannot meet the process requirements.
2. There is a high requirement for repeatability and consistency of the vacuum freeze dryer.
3. Upstream separation and purification or downstream packaging inspection equipment is provided by the importer, domestic freeze-drying equipment can not be matched with it.
Note: Select several major traps for imported brand vacuum freeze dryers:
1. As long as it is imported, quality is good. Many foreign second and third-line vacuum freeze dryers are far inferior to domestic ones in terms of quality and workmanship.
2. Imported brands are better than domestic brands. In addition to a handful of 2-3 overseas brands that have nationwide service capabilities, other manufacturers have basically no service capabilities.
3. The price of imported brands must be higher than the price of domestic brands. The price of foreign first-line brands is higher than that of domestic first-line brands, which is generally 30-40% higher. The price of domestic first-line brands and foreign second-tier brands is basically the same and higher than the foreign three-line brand prices. The reason for this pattern is that in the past five years, there are individual manufacturers in the country have a greater improvement in performance, workmanship, and its product quality and performance have reached the international level, while the foreign second and third line of the brand's products basically no fundamental changes.
Domestic brands vacuum freeze dryer selection errors:
1. During the selection process, the lower the price, the better. The low price means that the functional configuration is very low and may not meet the requirements for use.
2. Select the brand to use price as the first criterion. The prices of manufacturers with large-scale products of the same type are relatively low, because the large-scale production can control costs. If the manufacturer of a small-scale product is found to have a lower price than the manufacturer of a larger scale during the selection process, it should be noted that there may be some parts that customers cannot pay attention to have been replaced with low-quality, low-quality accessories.
3. Do not pay attention to manufacturer service. Small-scale manufacturers do not have service capabilities. Once a device fails, customers cannot use the device normally.
4. Try to save money during the selection process and only select the basic model, not taking into account the possible higher demand in the future.
Vacuum freeze dryer non-standard customized service experimental vacuum freeze dryer according to customer needs, the whole machine provides the following non-standard customized services:
1. Cold traps can be customized temperature range: -100 to -165 °C.
2. Non-standard freeze-drying warehouse production, including: freeze-drying bin size, material, structure type, pallet material and size.
3. The overall size can be customized according to the actual site requirements of customers.
4. Users need to connect the equipment and vacuum freeze dryer matching custom services.
5. Overall personalized service, including: personalized design of the whole model, personalized display interface design.
6. Non-standard customized service of vacuum unit, can customize the pumping speed and appearance of vacuum pump according to customer's demand.
7. Customize vacuum freeze dryer for organic solvent according to customer's requirement.
8. According to customer needs can be customized high reliability vacuum freeze dryer. The refrigeration unit, vacuum unit and electrical system are all equipped with two machines. One group fails and automatically switches to the second group to ensure the long-term stability and reliability of the system.
The pilot-type vacuum freeze dryer can provide the following non-standard customized services according to customer needs:
1. Cold traps can be customized temperature range: -100 to -130 °C.
2. Separator can be customized temperature range: -60 to -100 °C.
3. According to customer needs can be customized 0.1? Silicon oil vacuum freeze dryer.
4. CIP+SIP (0.1 to 1 silicone oil vacuum freeze dryer) minicomputers can be customized according to customer requirements.
3. The overall size can be customized according to the actual site requirements of customers.
4. Users need to connect the equipment and vacuum freeze dryer matching custom services.
5. Overall personalized service, including: personalized design of the whole model, personalized display interface design.
6. According to customer needs, customized nitrogen spray vacuum freeze dryer.
7. Customize vacuum freeze dryer for organic solvent according to customer's requirement.
8. According to customer needs can be customized high reliability vacuum freeze dryer. Refrigeration units, vacuum units, circulation units and electrical systems are all dual standby machines, one set of which has failed. Automatically switch to the second group to ensure long-term stability and reliability of the system.
The production type vacuum freeze dryer can provide the following non-standard services according to customer needs:
1. According to the customer site design vacuum freeze dryer.
2. According to customer freeze-drying process and docking equipment design vacuum freeze dryer.
3 can be customized tunnel food vacuum freeze dryer.
Non-standard customized service process:
1. The supply and demand sides communicate and confirm the demand information.
2. According to the demand information, provide the development cycle and quotation.
3. Both parties confirm the detailed demand information generated and sign the contract.
4. After the completion of the development, the customer enters the factory for inspection.
5. Equipment transportation and factory installation.
6. On-site commissioning and training.
7. Service tracking during equipment operation.
Freeze-drying process optimization service can be used to optimize the freeze-drying process for different formulation materials. Optimization includes:
1. Determination of eutectic point temperature.
2. Determination of eutectic point temperature.
3. Pre-freezing temperature and pre-freezing time optimization.
4. The heating rate, vacuum value and heating time of the drying stage are optimized.
The aim of the freeze-drying process optimization is to ensure that the appearance of the product after lyophilization, the increase in activity, the loss of nutrients and the control of the product moisture content, and on this basis increase the production efficiency or provide basis for the amplification of production.
For each freeze-dried application field, Biomedical Solutions proposes different solutions.
For scientific research institutes and universities, Biomedical launched the FD and Lab series vacuum freeze dryers. FD series vacuum freeze-drying machine is suitable for experimental freeze-drying applications where the amount of sample is small and the freeze-drying process is relatively simple. In addition to the FD series directly drying directly in the cold trap, under normal circumstances the drying process is from room temperature to the product maximum allowable temperature, FD series can meet the demand to determine from the following points:
1. The product eutectic point and eutectic point temperature are not lower than -20°C.
2. In the case where the amount of sample loaded is less than 5 μl, no surface dissolution will occur during the establishment of the vacuum from the end of the pre-freeze.
3. The ultimate vacuum required for freeze-drying process is not less than 8Pa.
4. Freeze-drying process is relatively simple and does not require process control of pre-freezing temperature and vacuum.
FD Series Vacuum Freeze Dryer Difference Description:
1.FD3/4/5/8 is suitable for small test and pilot production with relatively low process requirements.
2.The FD-2 series is suitable for freeze-drying products containing a small amount of organic solvents, and can be pre-frozen at low temperature (in cold trap) for a small amount of sample (<1.5L). The main aspect of the FD-2 series over the FD-1 series is the configuration of a partition temperature control system and a PLC+ touch screen control system. The main difference between the FD-2 series and the Lab-1 series is that the FD-2 series is the basic model and cannot be configured for all the advanced functions Lab has (vacuum control system, pulse backfill system, defrost system, automatic drainage system, and APS. Automatic Control System).
3.FD-1 series is suitable for lyophilization applications with lower process requirements. This series provides the basic functions of lyophilization: pre-freezing in the cold trap, vacuuming, and trap trapping. The Lab-1 series can be selected for more advanced application functions.
Lab-1 Series Applications:
1. The degree of vacuum needs to be adjusted during lyophilization.
2. Sublimation and analytical drying require temperature control.
3. A higher ultimate vacuum is required during lyophilization.
4. Automatic defrosting, automatic drainage function.
5. Freeze-drying data and curve search function.
6. Pulsation backfill after lyophilization.
7. The product eutectic point and eutectic point temperature are not lower than -20°C.
8. Deliquescence occurs during the establishment of a vacuum in the trace sample.
9. Lab-1 series process optimization rate can reach 30%.
The Pilot1-2LD/Pilot1-2MD/Pilot2-4LD/Pilot2-4MD models are suitable for laboratory pilot tests. This series proposes solutions for the following problems.
1. After the product is pre-frozen, deliquescence occurs during transfer.
2. Trace samples deliquescence during the establishment of a vacuum.
3. The pre-freezing temperature needs to be adjusted during the pre-freezing of the sample.
4. Sample analysis requires a lower vacuum during drying.
5. Meet the laboratory requirements of full-featured and relatively small-footprint vacuum freeze dryer requirements.
6. The process optimization rate is 40-70%.
The Pilot series is suitable for small-scale and pilot-scale production and is suitable for the exploration and optimization of production processes for industrial materials, foods and health products (up to 65% process optimization rate).
The Pilot series of standard models are suitable for small-scale testing and pilot-scale R&D of pharmaceuticals and biological agents. Users can choose to use wall insulation and non-wall insulation according to the cleanliness requirements. The series of process optimization rate of the series can reach more than 90%, fully meet the GMP and FDA requirements.
The LYO series is mainly used for freeze-drying production. The basic type, CIP type and SIP type can be selected according to user requirements. Applications include freeze-drying of chemicals, biological drugs, biological agents, Chinese medicines, health products, high-grade foods, spices, feed additives, and industrial special applications.
Domestic and foreign vacuum freeze dryer selection guide vacuum freeze dryer market brand, many customers do not have the ability to select brands. From the perspective of market supply, it is mainly divided into: imported brands and domestic brands. The relative price of imported brands is relatively high and the performance is higher than that of domestic brands. Compared with imported brands, domestic brands have relatively low prices and relatively simple functions. The main basis for selecting an imported brand or a domestic brand is:
1. The process requirements of freeze-drying process are relatively high, and the domestic vacuum freeze-drying machine cannot meet the process requirements.
2. There is a high requirement for repeatability and consistency of the vacuum freeze dryer.
3. Upstream separation and purification or downstream packaging inspection equipment is provided by the importer, domestic freeze-drying equipment can not be matched with it.
Note: Select several major traps for imported brand vacuum freeze dryers:
1. As long as it is imported, quality is good. Many foreign second and third-line vacuum freeze dryers are far inferior to domestic ones in terms of quality and workmanship.
2. Imported brands are better than domestic brands. In addition to a handful of 2-3 overseas brands that have nationwide service capabilities, other manufacturers have basically no service capabilities.
3. The price of imported brands must be higher than the price of domestic brands. The price of foreign first-line brands is higher than that of domestic first-line brands, which is generally 30-40% higher. The price of domestic first-line brands and foreign second-tier brands is basically the same and higher than the foreign three-line brand prices. The reason for this pattern is that in the past five years, there are individual manufacturers in the country have a greater improvement in performance, workmanship, and its product quality and performance have reached the international level, while the foreign second and third line of the brand's products basically no fundamental changes.
Domestic brands vacuum freeze dryer selection errors:
1. During the selection process, the lower the price, the better. The low price means that the functional configuration is very low and may not meet the requirements for use.
2. Select the brand to use price as the first criterion. The prices of manufacturers with large-scale products of the same type are relatively low, because the large-scale production can control costs. If the manufacturer of a small-scale product is found to have a lower price than the manufacturer of a larger scale during the selection process, it should be noted that there may be some parts that customers cannot pay attention to have been replaced with low-quality, low-quality accessories.
3. Do not pay attention to manufacturer service. Small-scale manufacturers do not have service capabilities. Once a device fails, customers cannot use the device normally.
4. Try to save money during the selection process and only select the basic model, not taking into account the possible higher demand in the future.
Vacuum freeze dryer non-standard customized service experimental vacuum freeze dryer according to customer needs, the whole machine provides the following non-standard customized services:
1. Cold traps can be customized temperature range: -100 to -165 °C.
2. Non-standard freeze-drying warehouse production, including: freeze-drying bin size, material, structure type, pallet material and size.
3. The overall size can be customized according to the actual site requirements of customers.
4. Users need to connect the equipment and vacuum freeze dryer matching custom services.
5. Overall personalized service, including: personalized design of the whole model, personalized display interface design.
6. Non-standard customized service of vacuum unit, can customize the pumping speed and appearance of vacuum pump according to customer's demand.
7. Customize vacuum freeze dryer for organic solvent according to customer's requirement.
8. According to customer needs can be customized high reliability vacuum freeze dryer. The refrigeration unit, vacuum unit and electrical system are all equipped with two machines. One group fails and automatically switches to the second group to ensure the long-term stability and reliability of the system.
The pilot-type vacuum freeze dryer can provide the following non-standard customized services according to customer needs:
1. Cold traps can be customized temperature range: -100 to -130 °C.
2. Separator can be customized temperature range: -60 to -100 °C.
3. According to customer needs can be customized 0.1? Silicon oil vacuum freeze dryer.
4. CIP+SIP (0.1 to 1 silicone oil vacuum freeze dryer) minicomputers can be customized according to customer requirements.
3. The overall size can be customized according to the actual site requirements of customers.
4. Users need to connect the equipment and vacuum freeze dryer matching custom services.
5. Overall personalized service, including: personalized design of the whole model, personalized display interface design.
6. According to customer needs, customized nitrogen spray vacuum freeze dryer.
7. Customize vacuum freeze dryer for organic solvent according to customer's requirement.
8. According to customer needs can be customized high reliability vacuum freeze dryer. Refrigeration units, vacuum units, circulation units and electrical systems are all dual standby machines, one set of which has failed. Automatically switch to the second group to ensure long-term stability and reliability of the system.
The production type vacuum freeze dryer can provide the following non-standard services according to customer needs:
1. According to the customer site design vacuum freeze dryer.
2. According to customer freeze-drying process and docking equipment design vacuum freeze dryer.
3 can be customized tunnel food vacuum freeze dryer.
Non-standard customized service process:
1. The supply and demand sides communicate and confirm the demand information.
2. According to the demand information, provide the development cycle and quotation.
3. Both parties confirm the detailed demand information generated and sign the contract.
4. After the completion of the development, the customer enters the factory for inspection.
5. Equipment transportation and factory installation.
6. On-site commissioning and training.
7. Service tracking during equipment operation.
Freeze-drying process optimization service can be used to optimize the freeze-drying process for different formulation materials. Optimization includes:
1. Determination of eutectic point temperature.
2. Determination of eutectic point temperature.
3. Pre-freezing temperature and pre-freezing time optimization.
4. The heating rate, vacuum value and heating time of the drying stage are optimized.
The aim of the freeze-drying process optimization is to ensure that the appearance of the product after lyophilization, the increase in activity, the loss of nutrients and the control of the product moisture content, and on this basis increase the production efficiency or provide basis for the amplification of production.
The multifunctional hammer mill is widely used in crushing various biomass wood waste and straw material. The motor and the hammers are directly connected by the coupling. There is no dead angle during the crushing so the finished product is very fine. The corners of the hammers are welded with high hardness material like carbon tungsten alloy. The welding layer thickness is around 3mm. The lifetime is 7- 8 times by normal 65Mn overall quenching hammer. The rotor has made the balance test and can work backward. It`s the best choice to prepare milled material for pellet machine.
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